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Hypersensitivity to the active substances or any of the excipients.
Acute or chronic metabolic acidosis, including lactic acidosis or diabetic ketoacidosis, with or without coma.
Severe renal impairment (GFR with creatinine clearance <30 ml/min) (See Dosage & Administration and Precautions).
Acute conditions with the potential to alter renal function, such as: Dehydration; Severe infection; Shock; Intravascular administration of iodinated contrast agents (see Precautions).
Acute or chronic disease which may cause tissue hypoxia, such as: Heart failure; Respiratory failure; Recent myocardial infarction; Shock.
Hepatic impairment (see Dosage & Administration, Precautions and Adverse Reactions).
Acute alcohol intoxication, alcoholism.
Lactation (see Use in Pregnancy & Lactation).
